The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is not associated with a reduction in the risk of melanoma, according to the results of a large cohort study in the June 24 issue of the Journal of the National Cancer Institute.
When people know the results of genetic tests confirming they have inherited an increased risk of developing melanoma, they follow skin cancer screening recommendations more proactively -- much like those who have already been diagnosed with the potentially deadly disease, according to a study in Cancer Epidemiology, Biomarkers & Prevention.
Researchers describe the first successful use of a human patient's cloned infection-fighting T cells as the sole therapy to put an advanced solid-tumor cancer into long-term remission.
A novel small molecule inhibitor reduced both endogenous and drug-induced resistance to chemotherapy in a mouse model of melanoma. The NF-κB pathway is often active in human cancers and promotes resistance to cytotoxic chemotherapy drugs. Some cytostatic drugs, such as doxorubicin, induce NF-κB pathway activity.
Results of research into the associations between cancer and socio-economic deprivation and affluence have shown that, in contrast to cancers in older people, the numbers of new cases and deaths from the disease in teenagers and young adults decrease with increasing deprivation. Researchers also noted increases in the incidence of a number of cancers, including two potentially preventable cancers among younger people: cervical cancer and melanoma.
Researchers in the melanoma and skin cancer program at the University of Pittsburgh Cancer Institute combined two biotherapies, high-dose interferon alfa-2b and tremelimumab, and found the combination may be beneficial for patients with inoperable melanoma. The study has since moved into the second stage, where it will enroll 21 additional patients.
A chronic, inflammatory disease of unknown origin, rheumatoid arthritis affects about 1 percent of adults worldwide. Marked by joint destruction, RA often leads to disability and diminished quality of life. It can also lead to an early death from cancer.
Disabling a protein frequently found in melanoma tumors may make the cancer more vulnerable to chemotherapy, according to a pilot study led by researchers in the Duke Comprehensive Cancer Center. Melanoma often affects people on their extremities, with a common scenario being a mole that appears on the foot and then spreads up the leg.
